Limitations of Gene Therapy Cancer
This idea of a new treatment that is Gene Therapy Treatment for a sickness of Cancer or before it is a genetic diseases that they are vey different from normal cells because its more lethal for our body/ its a threat for us humans and any animals.
Numbers of new types of gene therapy treatments are being developed, meaning that the gene are usually taken into the cancer cell by a carrier called a vector. A vector is the most common type of carrier used in a gene therapy are viruses, because those viruses can easily enter cells and deliver genetic materials. the virus changed so they cant cause diseases but they may still cause mild flue like symptoms.
The problem on gene therapy is that clinical trials, 464 human trial protocols from NIH and FDA had been performed the treatment since may 15 2001 and they received a review. Other categories are HIV infection can be caused by the treatment. Cancer had been the most violent and important disease in the clinical trials of gene therapy, because getting approval for a human trial is easier for cancer than for other genetic disease.
Figure 1: Chart of human Gene Therapy Protocols
(this picture above is about the chart of human Gene Therapy protocols, it shows a pie chart about cancer, infectious, monogenic, marking and others in a human gene therapy protocols)
http://www.nature.com/gim/journal/v4/n6s/fig_tab/gim200288f1.html#figure-title
There had been remarkable development in our understanding of the molecular basis of human cancer and potential of using gene therapy to not only cure cancer but also prevent it. To make gene therapy a standard treatment for cancer patients, scientist have to improve the place and the technologies to perform a gene therapy treatment. But many ethical problems and concerns remains
The importance of a gene therapy are it's strategies in the treatment of malignancies. The fact that there are 823 cancer gene therapy clinical trials worldwide that are active or begin to recruiting patients. Strategies that have proved promising in the in vitro setting have stumble when exposed to the environment. Involving the delivery of plasmid DN that encodes the therapeutic protein product, the field of a gene therapy evolved to encompass not only to deliver of therapeutic DNA but also micro, short hairpin and small interfering RNAs and oligodeoxynucleotides.
MLA:
The FDA has not yet approved any human gene therapy product sale. Gene therapy is experimental and ha not proven very successful in clinical trials. A little progress has been made since the first gene therapy clinical trials began in 1990. I'm 1999, gene therapy suffered a major setback with the death of a 18 year old Jesse Gelsinger.
Video 1: FDA Case of Jesse Gelsinger
Another "blow up" came in January 2003, when the FDA placed a stop on all gene therapy treatments trials by using retroviral vectors on blood stem cells. They took this action after knowing that a second child treated in French gene therapy trial had developed a leukemia like condition. Both child and another had a similar conditions in August 2002 had been successfully treated by gene therapy for X linked severe combined immunodeficiency disease also known as bubble baby syndrome. The FDA biological responses modifiers advisory committee met at the end of February 2003 to discuss possible measure that could allow a number of retro viral gene therapy trials for treatments of life threatening diseases and germs to proceed with appropriate safeguards. In April of 3003 the FDA eased the ban on gene therapy trials using retroviral vectors in blood stem cell.
This idea of a new treatment that is Gene Therapy Treatment for a sickness of Cancer or before it is a genetic diseases that they are vey different from normal cells because its more lethal for our body/ its a threat for us humans and any animals.
Numbers of new types of gene therapy treatments are being developed, meaning that the gene are usually taken into the cancer cell by a carrier called a vector. A vector is the most common type of carrier used in a gene therapy are viruses, because those viruses can easily enter cells and deliver genetic materials. the virus changed so they cant cause diseases but they may still cause mild flue like symptoms.
The problem on gene therapy is that clinical trials, 464 human trial protocols from NIH and FDA had been performed the treatment since may 15 2001 and they received a review. Other categories are HIV infection can be caused by the treatment. Cancer had been the most violent and important disease in the clinical trials of gene therapy, because getting approval for a human trial is easier for cancer than for other genetic disease.
Figure 1: Chart of human Gene Therapy Protocols
(this picture above is about the chart of human Gene Therapy protocols, it shows a pie chart about cancer, infectious, monogenic, marking and others in a human gene therapy protocols)
http://www.nature.com/gim/journal/v4/n6s/fig_tab/gim200288f1.html#figure-title
There had been remarkable development in our understanding of the molecular basis of human cancer and potential of using gene therapy to not only cure cancer but also prevent it. To make gene therapy a standard treatment for cancer patients, scientist have to improve the place and the technologies to perform a gene therapy treatment. But many ethical problems and concerns remains
The importance of a gene therapy are it's strategies in the treatment of malignancies. The fact that there are 823 cancer gene therapy clinical trials worldwide that are active or begin to recruiting patients. Strategies that have proved promising in the in vitro setting have stumble when exposed to the environment. Involving the delivery of plasmid DN that encodes the therapeutic protein product, the field of a gene therapy evolved to encompass not only to deliver of therapeutic DNA but also micro, short hairpin and small interfering RNAs and oligodeoxynucleotides.
MLA:
- Nature.com. Nature Publishing Group, n.d. Web. 11 Oct. 2014. http://www.nature.com/gim/journal/v4/n6s/full/gim200288a.html
- "Chapter 9." Cancer Gene Therapy – Key Biological Concepts in the Design of Multifunctional Non-Viral Delivery Systems. N.p., n.d. Web. 11 Oct. 2014. http://www.intechopen.com/books/gene-therapy-tools-and-potential-applications/cancer-gene-therapy-key-biological-concepts-in-the-design-of-multifunctional-non-viral-delivery-syst
- "The Promise of Gene Therapy." CISN -. N.p., n.d. Web. 10 Oct. 2014. http://cisncancer.org/research/new_treatments/gene_therapy/promise.html
The FDA has not yet approved any human gene therapy product sale. Gene therapy is experimental and ha not proven very successful in clinical trials. A little progress has been made since the first gene therapy clinical trials began in 1990. I'm 1999, gene therapy suffered a major setback with the death of a 18 year old Jesse Gelsinger.
(This video above is about a FDA case of Gene Therapy problem of Jesse Gelsinger, its a tragedy case that Jesse Gelsinger needs to do a Gene Therapy procedure to cure his cancer issue)
https://www.youtube.com/watch?v=ola8EvMZ7dgAnother "blow up" came in January 2003, when the FDA placed a stop on all gene therapy treatments trials by using retroviral vectors on blood stem cells. They took this action after knowing that a second child treated in French gene therapy trial had developed a leukemia like condition. Both child and another had a similar conditions in August 2002 had been successfully treated by gene therapy for X linked severe combined immunodeficiency disease also known as bubble baby syndrome. The FDA biological responses modifiers advisory committee met at the end of February 2003 to discuss possible measure that could allow a number of retro viral gene therapy trials for treatments of life threatening diseases and germs to proceed with appropriate safeguards. In April of 3003 the FDA eased the ban on gene therapy trials using retroviral vectors in blood stem cell.
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